OUR TEAM
OUR TEAM
WELCOME TO
A leading manufacturer and supplier of
human untagged ubiquitin-proteasome complexes
About us
The Proteasome Center specializes in isolating untagged 19S, 20S, 26S, and COP9 signalosome protein complexes of the ubiquitin-proteasome system from human red blood cells, as well as untagged 20S immunoproteasome from the human spleen.
We deliver exclusively high-quality proteasome proteins to leading pharmaceutical companies and research laboratories all around the world (USA, Europe, UK, China).
The ubiquitin-proteasome system
is a key cellular mechanism for regulating protein levels and quality. In this system, proteins destined for degradation are tagged with ubiquitin that signals the cell to transport these tagged proteins to the proteasome. The proteasome is a large complex that breaks down these proteins into smaller fragments, which the cell can then reuse.
This system is crucial for controlling various cellular processes, including cell cycle regulation, DNA repair, and response to stress.
The proteasome
is a large protein complex responsible for degrading and recycling unwanted or damaged proteins in cells. It consists of a cylindrical 20S core particle, where protein breakdown occurs, and one or two 19S regulatory particles that recognize and process proteins tagged with ubiquitin.
This complex plays a key role in maintaining cellular health by controlling protein quality and regulating various cellular processes.
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Our customers
Company leaders
Dr. amnon golan
Founder and CEo
Dr. Amnon Golan received his PhD from The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology working in the laboratory of a Nobel Prize winner - Avram Hershko. He then followed a postdoctoral research fellowship at Yale University.
He has focused his research and career on human homologous proteins and complexes in general, and the protein degradation system through the ubiquitin pathway, in particular.
Dr. Golan holds extensive hands-on experience in isolating protein complexes of the ubiquitin pathway through fractionation.
Dr. oleg chmelnik
CTO, Senior scientist
Dr. Oleg Chmelnik holds a PhD in Biotechnology and Food Engineering from the Technion - Israel Institute of Technology. He specializes in protein engineering, protein purification, directed evolution of enzymes, organic synthesis, and chemical manipulations of carbohydrates.
